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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

Question 1

A researcher is studying the genetic relatedness of different isolates of Mycobacterium tuberculosis. Which of the following molecular typing methods provides the highest discriminatory power for distinguishing between closely related strains?

A. Pulsed-field gel electrophoresis (PFGE)
B. Whole-genome sequencing (WGS)
C. Restriction fragment length polymorphism (RFLP) analysis
D. Spoligotyping

Question 2

A patient with recent abdominal surgery develops a fever, abdominal pain, and a wound infection. Gram stain of the wound exudate reveals a mixture of Gram-negative rods and Gram-positivebacilli. Anaerobic culture yields a foul-smelling, Gram-negative rod that is bile-esculin positive. The MOST likely organism is:

A. Escherichia coli
B. Clostridium perfringens
C. Peptostreptococcus anaerobius
D. Bacteroides fragilis

Question 3

A patient with a history of solid organ transplantation develops diarrhea and abdominal cramps. Stool studies are negative for bacterial pathogens and C. difficile toxins. Colonoscopy reveals characteristic cytomegalic inclusion bodies in colonic biopsies. The MOST likely causative agent is:

A. Adenovirus
B. Cytomegalovirus (CMV)
C. Norovirus
D. Rotavirus

Question 4

A serum sample from an asymptomatic patient screened for syphilis yields a reactive Rapid Plasma Reagin (RPR) test result with a titer of 1:16, but a non-reactive Treponema pallidum particle agglutination (TP-PA) test. What is the most likely interpretation of these findings?

A. Prozone phenomenon in the TP-PA test
B. Biological false positive (BFP) RPR reaction
C. Successfully treated past syphilis infection
D. Early primary syphilis (before treponemal antibodies develop)

Question 5

Which of the following organisms is an obligate intracellular bacterium transmitted by arthropod vectors and is a common cause of Rocky Mountain Spotted Fever?

A. Borrelia burgdorferi
B. Chlamydia trachomatis
C. Coxiella burnetii
D. Rickettsia rickettsii

Solutions: